NIHR Evaluation, Trials and Studies Coordinating Centre

159 published titles

Systematic review of respite care in the frail elderly

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1 edition

Neuroleptics in the treatment of aggressive challenging behaviour for people with intellectual disabilities : a randomised controlled trial (NACHBID)

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1 edition

Randomised controlled trial to determine the clinical effectiveness and cost-effectiveness of selective serotonin reuptake inhibitors plus supportive care, versus supportive care alone, for mild to mo

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1 edition

Diagnostic strategies using DNA testing for hereditary haemochromatosis in at-risk populations : a systematic review and economic evaluation

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1 edition

Enhanced external counterpulsation for the treatment of stable angina and heart failure : a systematic review and economic analysis

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1 edition

Development of a decision support tool for primary care management of patients with abnormal liver function tests without clinically apparent liver disease : a record-linkage population cohort study a

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1 edition

A systematic review of presumed consent systems for deceased organ donation

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1 edition

Systematic review and individual patient data meta-analysis of diagnosis of heart failure, with modelling of implications of different diagnostic strategies in primary care

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1 edition

A multicentre randomised controlled trial of the use of continuous positive airway pressure and non-invasive positive pressure ventilation in the early treatment of patients presenting to the emergenc

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1 edition

A randomised controlled trial to compare minimally invasive glucose monitoring devices with conventional monitoring in the management of insulin-treated diabetes mellitus (MITRE)

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1 edition

Sensitivity analysis in economic evaluation : an audit of NICE current practice and a review of its use and value in decision-making

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1 edition

The effects of biofeedback for the treatment of essential hypertension : a systematic review

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1 edition

Vitamin K to prevent fractures in older women : systematic review and economic evaluation

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1 edition

A randomised controlled trial of the use of aciclovir and/or prednisolone for the early treatment of Bell's palsy : the BELLS study

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1 edition

Endovascular stents for abdominal aortic aneurysms : a systematic review and economic model

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1 edition

Screening to prevent spontaneous preterm birth : systematic reviews of accuracy and effectiveness literature with economic modelling

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1 edition

The effectiveness and cost-effectiveness of cochlear implants for severe to profound deafness in children and adults : a systematic review and economic model

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1 edition

Randomised preference trial of medical versus surgical termination of pregnancy less than 14 weeks' gestation (TOPS)

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1 edition

Randomised controlled trial of the use of three dressing preparations in the management of chronic ulceration of the foot in diabetes

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1 edition

VenUS II : a randomised controlled trial of larval therapy in the management of leg ulcers

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1 edition

A prospective randomised controlled trial and economic modelling of antimicrobial silver dressings versus non-adherent control dressings for venous leg ulcers : the VULCAN trial

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1 edition

ARTISTIC : a randomised trial of human papillomavirus (HPV) testing in primary cervical screening

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1 edition

The clinical effectiveness of glucosamine and chondroitin supplements in slowing or arresting progression of osteoarthritis of the knee : a systematic review and economic evaluation

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1 edition

Clinical and cost-effectiveness of epoprostenol, iloprost, bosentan, sitaxentan and sildenafil for pulmonary arterial hypertension within their licensed indications : a systematic review and economic

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1 edition

Communication of carrier status information following universal newborn screening for sickle cell disorders and cystic fibrosis : qualitative study of experience and practice

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1 edition

Antiviral drugs for the treatment of influenza : a systematic review and economic evaluation

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Development of a toolkit and glossary to aid in the adaptation of health technology assessment (HTA) reports for use in different contexts

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1 edition

Colour vision testing for diabetic retinopathy : a systematic review of diagnostic accuracy and economic evaluation

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1 edition

Systematic review of the effectiveness and cost-effectiveness of weight management schemes for the under fives : a short report

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1 edition

Are adverse effects incorporated in economic models? : an initial review of current practice

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1 edition

Cessation of attention deficit hyperactivity disorder drugs in the young (CADDY) : a pharmacoepidemiological and qualitative study

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1 edition

Systematic review of the clinical effectiveness and cost-effectiveness of photodynamic diagnosis and urine biomarkers (FISH, ImmunoCyt, NMP22) and cytology for the detection and follow-up of bladder c

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1 edition

Effectiveness and cost-effectiveness of arthroscopic lavage in the treatment of osteoarthritis of the knee: a mixed methods study of the feasibility of conducting a surgical placebo-controlled trial (

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1 edition

The effectiveness and cost-effectiveness of behavioural interventions for the prevention of sexually transmitted infections in young people aged 13-19 : a systematic review and economic evaluation

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1 edition

Dissemination and publication of research findings : an updated review of related biases

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1 edition

A randomised 2 x 2 trial of community versus hospital pulmonary rehabilitation for chronic obstructive pulmonary disease followed by telephone or conventional follow-up

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1 edition

The effectiveness and cost effectiveness of biomarkers for the prioritisation of patients awaiting coronary revascularisation : a systematic review and decision model

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1 edition

Comparison of case note review methods for evaluating quality and safety in health care

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1 edition

Clinical effectiveness and cost-effectiveness of continuous subcutaneous insulin infusion for diabetes: systematic review and economic evaluation

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1 edition

Self-monitoring of blood glucose in type 2 diabetes : systematic review

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1 edition

North of England and Scotland Study of Tonsillectomy and Adeno-tonsillectomy in Children (NESSTAC) : a pragmatic randomised controlled trial with a parallel non-randomised preference study

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1 edition

Multicentre randomised controlled trial of the clinical and cost-effectiveness of a bypass-surgery-first versus a balloon-angioplasty-first revascularisation strategy for severe limb ischaemia due to

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1 edition

A randomised controlled multicentre trial of treatments for adolescent anorexia nervosa including assessment of cost-effectiveness and patient acceptability - the TOuCAN trial

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1 edition

Randomised controlled trials for policy interventions : a review of reviews and meta-regression

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1 edition

Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs (NSAIDs) for the reduction of morphine-related side effects after major surgery : a systematic review

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1 edition

A systematic review of outcome measures used in forensic mental health research with consensus panel opinion

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1 edition

The clinical effectiveness and cost-effectiveness of topotecan for small cell lung cancer: a systematic review and economic evaluation

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1 edition

Antenatal screening for haemoglobinopathies in primary care : a cohort study and cluster randomised trial to inform a simulation model : the Screening for Haemoglobinopathies in First Trimester (SHIFT

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1 edition

Early referral strategies for management of people with markers of renal disease: a systematic review of the evidence of clinical effectiveness, cost-effectiveness and economic analysis

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1 edition

A systematic review and economic evaluation of the clinical effectiveness and cost-effectiveness for aldosterone antagonists for postmyocardial infarction heart failure

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1 edition

Avoiding and identifying errors in health technology assessment models : qualitative study and methodological review

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1 edition

BoTULS : a multicentre randomised controlled trial to evaluate the clinical effectiveness and cost-effectiveness of treating upper limb spasticity due to stroke with botulinum toxin type A

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1 edition

Single technology appraisals : a supplement to Health technology assessment journal

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1 edition

Weighting and valuing quality-adjusted life-years using stated preference methods : preliminary results from the social value of a QALY project

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1 edition

Systematic review of the clinical effectiveness and cost-effectiveness of rapid point-of-care tests for the detection of genital chlamydia infection in women and men

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1 edition

School-linked sexual health services for young people (SSHYP) : a survey and systematic review concerning current models, effectiveness and research opportunities

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1 edition

Systematic review and cost-effectiveness of 'pill-in-the-pocket' strategy for paroxysmal atrial fibrillation compared to episodic in-hospital treatment or continuous antiarrhythmic drug therapy

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1 edition

H1N1 influenza and pandemic flu

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1 edition

Randomised controlled trial and parallel economic evaluation of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR)

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1 edition

Systematic review and economic modelling of the effectiveness and cost-effectiveness of non-surgical treatments for women with stress urinary incontinence

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1 edition

A multicentred randomised controlled trial of a primary care-based cognitive behavioural programme for low back pain. The Back Skills Training (BeST) trial

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1 edition

Recombinant human growth hormone for the treatment of growth disorders in children : a systematic review and economic evaluation

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1 edition

A pragmatic randomised controlled trial to compare antidepressants with a community-based psychosocial intervention for the treatment of women with postnatal depression: the RESPOND trial

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1 edition

Group cognitive behavioural therapy for postnatal depression: a systematic review of clinical effectiveness, cost-effectiveness and value of information analyses

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1 edition

Screening for hyperglycaemia in pregnancy : a rapid update for the National Screening Committee

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1 edition

HINI influenza and pandemic flu

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2 editions

Intensity-modulated radiotherapy for the treatment of prostate cancer : a systematic review and economic evaluation

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1 edition

Computerised decision support systems in order communication for diagnostic, screening or monitoring test ordering : systematic reviews of the effects and cost-effectiveness of systems

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1 edition

Relapse prevention in UK Stop Smoking Services : current practice, systematic reviews of effectiveness and cost-effectiveness analysis

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1 edition

A systematic review of positron emission tomography (PET) and positron emission tomography/computed tomography (PET/CT) for the diagnosis of breast cancer recurrence

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1 edition

Systematic review of the links between human resource management practices and performance

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1 edition

LIFELAX - diet and LIFEstyle versus LAXatives in the management of chronic constipation in older people: randomised controlled trial

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1 edition

Cost-effectiveness of screening high-risk HIV-positive men who have sex with men (MSM) and HIV-positive women for anal cancer

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1 edition

An evidence synthesis of qualitative and quantitative research on component intervention techniques, effectiveness, cost-effectiveness, equity and acceptability of different versions of health-related

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1 edition

A multicentre randomised controlled trial and economic evaluation of ion-exchange water softeners for the treatment of eczema in children : the Softened Water Eczema Trial (SWET)

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1 edition

Accuracy of bacterial DNA testing for central venous catheter-associated bloodstream infection in children with cancer

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1 edition

Etanercept, infliximab and adalimumab for the treatment of psoriatic arthritis : a systematic review and economic evaluation

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1 edition

Growth monitoring for short stature : update of a systematic review and economic model

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1 edition

A randomised controlled trial of post-operative radiotherapy following breast-conserving surgery in a minimum-risk population : quality of life at 5 years in the PRIME trial

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1 edition

VenUS III : a randomised controlled trial of therapeutic ultrasound in the management of venous leg ulcers

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1 edition

Adalimumab, etanercept, infliximab, rituximab and abatacept for the treatment of rheumatoid arthritis after the failure of a tumour necrosis factor inhibitor : a systematic review and economic evaluat

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1 edition

Processes in recruitment to randomised controlled trials of medicines for children (RECRUIT) : a qualitative study

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1 edition

The RATPAC (Randomised Assessment of Treatment using Panel Assay of Cardiac markers) trial : a randomised controlled trial of point-of-care cardiac markers in the emergency department

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1 edition

Evidence Review Group approaches to the critical appraisal of manufacturer submissions for the NICE STA process : a mapping study and thematic analysis

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1 edition

A pragmatic single-blind randomised controlled trial and economic evaluation of the use of leukotriene receptor antagonists in primary care at steps 2 and 3 of the national asthma guidelines (ELEVATE

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1 edition

Evaluation of patient reporting of adverse drug reactions to the UK 'Yellow Card Scheme' : literature review, descriptive and qualitative analyses, and questionnaire surveys

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1 edition

Hysterectomy, endometrial ablation and Mirena for heavy menstrual bleeding : a systematic review of clinical effectiveness and cost-effectiveness analysis

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1 edition

An economic evaluation of positron emission tomography (PET) and positron emission tomography/computed tomography (PET/CT) for the diagnosis of breast cancer recurrence

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1 edition

Clinical effectiveness and cost-effectiveness of imatinib dose escalation for the treatment of unresectable and/or metastatic gastrointestinal stromal tumours that have progressed on treatment at a do

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1 edition

Conservative treatment for urinary incontinence in men after prostate surgery (MAPS) : two parallel randomised controlled trials

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1 edition

Bone-anchored hearing aids (BAHAs) for people who are bilaterally deaf : a systematic review and economic evaluation

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1 edition

Diagnostic management strategies for adults and children with minor head injury : a systematic review and an economic evaluation

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1 edition

A study of the safety and harms of antidepressant drugs for older people : a cohort study using a large primary care database

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1 edition

Development and evaluation by a cluster randomised trial of a psychosocial intervention in children and teenagers experiencing diabetes : the DEPICTED study

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1 edition

Identification of risk factors by systematic review and development of risk-adjusted models for surgical site infection

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1 edition

Clopidogrel and modified-release dipyridamole for the prevention of occlusive vascular events (review of Technology Appraisal No. 90) : a systematic review and economic analysis

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1 edition

EVerT: cryotherapy versus salicylic acid for the treatment of verrucae : a randomised controlled trial

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1 edition

The clinical effectiveness and cost-effectiveness of different surveillance mammography regimens after the treatment for primary breast cancer : systematic reviews, registry database analyses and econ

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1 edition

Hemiarthroplasty and total hip arthroplasty for treating primary intracapsular fracture of the hip : a systematic review and cost-effectiveness analysis

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1 edition

Adaptive e-learning to improve dietary behaviour : a systematic review and cost-effectiveness analysis

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1 edition

Insulin sensitisers in the treatment of non-alcoholic fatty liver disease : a systematic review

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1 edition

The clinical effectiveness and cost-effectiveness of management strategies for sciatica : systematic review and economic model

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1 edition

A systematic review and economic evaluation of cilostazol, naftidrofuryl oxalate, pentoxifylline and inositol nicotinate for the treatment of intermittent claudication in people with peripheral arteri

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1 edition

The clinical effectiveness and cost-effectiveness of bortezomib and thalidomide in combination regimens with an alkylating agent and a corticosteroid for the first-line treatment of multiple myeloma :

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1 edition

Lapatinib and trastuzumab in combination with an aromatase inhibitor for the first-line treatment of metastatic hormone receptor-positive breast cancer which over-expresses human epidermal growth fact

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1 edition

Evaluating meta-ethnography : systematic analysis and synthesis of qualitative research

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1 edition

The clinical effectiveness and cost-effectiveness of exercise referral schemes : a systematic review and economic evaluation

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1 edition

A 1-year follow-on study from a randomised, head-to-head, multicentre, open-label study of two pandemic influenza vaccines in children

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1 edition

Development of a social inclusion index to capture subjective and objective life domains (Phase II) : psychometric development study

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1 edition

Pulse oximetry as a screening test for congenital heart defects in newborn infants : a test accuracy study with evaluation of acceptability and cost-effectiveness

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1 edition

Verteporfin photodynamic therapy for neovascular age-related macular degeneration : cohort study for the UK

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1 edition

What is the clinical effectiveness and cost effectiveness of using drugs in treating obese patients in primary care? : a systematic review

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1 edition

Non-invasive diagnostic assessment tools for the detection of liver fibrosis in patients with suspected alcohol-related liver disease : a systematic review and economic evaluation

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1 edition

A systematic review of prevention and intervention strategies for populations at high risk of engaging in violent behaviour : update 2002-8

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1 edition

An evaluation of the feasibility, cost and value of information of a multicentre randomised controlled trial of intravenous immunoglobulin for sepsis (severe sepsis and septic shock) : incorporating a

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1 edition

Group art therapy as an adjunctive treatment for people with schizophrenia : a randomised controlled trial (MATISSE)

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1 edition

The UK EndoVascular Aneurism Repair (EVAR) trials : randomised trials of EVAR versus standard therapy

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1 edition

A pragmatic randomised controlled trial to evaluate the cost-effectiveness of a physical activity intervention as a tratment for depression : the treating depression with physical activity (TREAD) tri

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1 edition

Management of frozen shoulder : a systematic review and cost-effectiveness analysis

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1 edition

A systematic review of the clinical effectiveness and cost-effectiveness of Pharmalgen [superscript circled R] for the treatment of bee and wasp venom allergy

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1 edition

CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study : the effect of tranexamic acid in traumatic brain injury - a nested, randomised, placebo

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1 edition

EOS 2D/3D X-ray imaging system : a systematic review and economic evaluation

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1 edition

Systematic review and validation of prediction rules for identifying children with serious infections in emergency departments and urgent-access primary care

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1 edition

Outcomes of social care for adults : developing a preference-weighted measure

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1 edition

Elucigene FH20 and LIPOchip for the diagnosis of familial hypercholesterolaemia : a systematic review and economic evaluation

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1 edition

Clinical effectiveness and cost-effectiveness of endobronchial and endoscopic ultrasound relative to surgical staging in potentially resectable lung cancer : results from the ASTER randomised controll

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1 edition

The effectiveness of interventions to treat severe acute malnutrition in young children : a systematic review

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1 edition

The clinical effectiveness and cost-effectiveness of home-based, nurse-led health promotion for older people : a systematic review

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1 edition

The effectiveness and cost-effectiveness of donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer's disease (review of Technology appraisal No. 111) : a systematic review a

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1 edition

Dasatinib and nilinib for imatinib-resistant or -intolerant chronic myeloid leukaemia : a systematic review and economic evaluation

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1 edition

Dasatinib, high-dose imatinib and nilotinib for the treatment of imatinib-resistant chronic myeloid leukaemia : a systematic review and economic evaluation

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1 edition

Screening for cystic fibrosis-related diabetes : a systematic review

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1 edition

A methodological study to compare survey-based and observation-based evaluations of organisational and safety cultures and then compare both approaches with markers of the quality of care

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1 edition

Dasatinib and nilotinib for imatinib-resistant or -intolerant chronic myeloid leukaemia : a systematic review and economic evaluation

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1 edition

Clinical effectiveness, cost-effectiveness and service users' perceptions of early, well-resourced communication therapy following a stoke : a randomised controlled trial (the ACT NoW study)

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1 edition

Mode of data elicitation, acquisition and response to surveys : a systematic review

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1 edition

The clinical effectiveness and cost-effectiveness of low-intensity psychological interventions for the secondary prevention of relapse after depression : a systematic review

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1 edition

Surveillance for ocular hypertension : an evidence synthesis and economic evaluation

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1 edition

The measurement of patients' expectations for health care : a review and psychometric testing of a measure of patients' expectations

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1 edition

Interventions to reduce or prevent obesity in pregnant women : a systematic review

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1 edition

Developing and testing methods for deriving preference-based measures of health from condition-specific measures (and other patient-based measures of outcome)

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1 edition

Non-pharmacological interventions to reduce the risk of diabetes in people with impaired glucose regulation : a systematic review and economic evaluation

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1 edition

The clinical effectiveness and cost-effectiveness of technologies used to visualise the seizure focus in people with refractory epilepsy being considered for surgery : a systematic review and decision

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1 edition

The effectiveness and cost-effectiveness of enzyme and substrate replacement therapies : a longitudinal cohort study of people with lysosomal storage disorders

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1 edition

Effectiveness and cost-effectiveness of computer and other electronic aids for smoking cessation : a systematic review and network meta-analysis

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1 edition

Influence of reported study design characteristics on intervention effect estimates from randomised controlled trials : combined analysis of meta-epidemiological studies

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1 edition

Rituximab for the first-line treatment of stag III-IV follicular lymphoma (review of techonology appraisal number 110) : a systematic review and economic evaluation

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1 edition

A pilot randomised controlled trial in intensive care patients comparing 7 days' treatment with empirical antibiotics with 2 days' treatment for hospital-acquired infection of unknown origin

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1 edition

Systematic review and economic modelling of the relative clinical benefit and cost-effectiveness of laparoscopic surgery and robotic surgery for removal of the prostate in men with localised prostate

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1 edition

The use of MElatonin in children with Neurodevelopmental Disorders and impaired Sleep : a randomised, double-blind, placebo-controlled, parallel study (MENDS)

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1 edition

The clinical effectiveness and cost-effectiveness of primary stroke prevention in children with sickle cell disease : a systematic review and economic evaluation

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1 edition

Adapting health promotion interventions to meet the needs of ethnic minority groups : mixed-methods evidence synthesis

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1 edition

Systematic review of head cooling in adults after traumatic brain injury and stroke

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1 edition

Informing a decision framework for when NICE should recommend the use of health technologies only in the context of an appropriately designed programme of evidence development

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1 edition

Types of urethral catheter for reducing symptomatic urinary tract infections in hospitalised adults requiring short-term catheterisation : multicentre randomised controlled trial and economic evaluati

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1 edition

REMCARE : reminiscence groups for people with dementia and their family caregivers - effectiveness and cost-effectiveness pragmatic multicentre randomised trial

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1 edition

Dasatinib, nilotinib and standard-dose imatinib for the first-line treatment of chronic myeloid leukaemia : systematic reviews and economic analyses

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1 edition

Managing Injuries of the Neck Trial (MINT) : a randomised controlled trial of treatments for whiplash injuries

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1 edition

What is the value of routinely testing full blood count, electrolytes and urea, and pulmonary function tests before elective surgery in patients with no apparent clinical indication and in subgroups o

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1 edition