NIHR Health Technology Assessment Programme

134 published titles

Randomised controlled trial to determine the clinical effectiveness and cost-effectiveness of selective serotonin reuptake inhibitors plus supportive care, versus supportive care alone, for mild to mo

(Contributor)

1 edition

Systematic review and individual patient data meta-analysis of diagnosis of heart failure, with modelling of implications of different diagnostic strategies in primary care

(Contributor)

1 edition

A multicentre randomised controlled trial of the use of continuous positive airway pressure and non-invasive positive pressure ventilation in the early treatment of patients presenting to the emergenc

(Contributor)

1 edition

Sensitivity analysis in economic evaluation : an audit of NICE current practice and a review of its use and value in decision-making

(Contributor)

1 edition

A randomised controlled trial of the use of aciclovir and/or prednisolone for the early treatment of Bell's palsy : the BELLS study

(Contributor)

1 edition

Endovascular stents for abdominal aortic aneurysms : a systematic review and economic model

(Contributor)

1 edition

Screening to prevent spontaneous preterm birth : systematic reviews of accuracy and effectiveness literature with economic modelling

(Contributor)

1 edition

The effectiveness and cost-effectiveness of cochlear implants for severe to profound deafness in children and adults : a systematic review and economic model

(Contributor)

1 edition

Randomised preference trial of medical versus surgical termination of pregnancy less than 14 weeks' gestation (TOPS)

(Contributor)

1 edition

Randomised controlled trial of the use of three dressing preparations in the management of chronic ulceration of the foot in diabetes

(Contributor)

1 edition

VenUS II : a randomised controlled trial of larval therapy in the management of leg ulcers

(Contributor)

1 edition

A prospective randomised controlled trial and economic modelling of antimicrobial silver dressings versus non-adherent control dressings for venous leg ulcers : the VULCAN trial

(Contributor)

1 edition

ARTISTIC : a randomised trial of human papillomavirus (HPV) testing in primary cervical screening

(Contributor)

1 edition

The clinical effectiveness of glucosamine and chondroitin supplements in slowing or arresting progression of osteoarthritis of the knee : a systematic review and economic evaluation

(Contributor)

1 edition

Clinical and cost-effectiveness of epoprostenol, iloprost, bosentan, sitaxentan and sildenafil for pulmonary arterial hypertension within their licensed indications : a systematic review and economic

(Contributor)

1 edition

Communication of carrier status information following universal newborn screening for sickle cell disorders and cystic fibrosis : qualitative study of experience and practice

(Contributor)

1 edition

Antiviral drugs for the treatment of influenza : a systematic review and economic evaluation

(Contributor)

1 edition

Development of a toolkit and glossary to aid in the adaptation of health technology assessment (HTA) reports for use in different contexts

(Contributor)

1 edition

Colour vision testing for diabetic retinopathy : a systematic review of diagnostic accuracy and economic evaluation

(Contributor)

1 edition

Systematic review of the effectiveness and cost-effectiveness of weight management schemes for the under fives : a short report

(Contributor)

1 edition

Are adverse effects incorporated in economic models? : an initial review of current practice

(Contributor)

1 edition

Cessation of attention deficit hyperactivity disorder drugs in the young (CADDY) : a pharmacoepidemiological and qualitative study

(Contributor)

1 edition

Systematic review of the clinical effectiveness and cost-effectiveness of photodynamic diagnosis and urine biomarkers (FISH, ImmunoCyt, NMP22) and cytology for the detection and follow-up of bladder c

(Contributor)

1 edition

Effectiveness and cost-effectiveness of arthroscopic lavage in the treatment of osteoarthritis of the knee: a mixed methods study of the feasibility of conducting a surgical placebo-controlled trial (

(Contributor)

1 edition

The effectiveness and cost-effectiveness of behavioural interventions for the prevention of sexually transmitted infections in young people aged 13-19 : a systematic review and economic evaluation

(Contributor)

1 edition

Dissemination and publication of research findings : an updated review of related biases

(Contributor)

1 edition

A randomised 2 x 2 trial of community versus hospital pulmonary rehabilitation for chronic obstructive pulmonary disease followed by telephone or conventional follow-up

(Contributor)

1 edition

The effectiveness and cost effectiveness of biomarkers for the prioritisation of patients awaiting coronary revascularisation : a systematic review and decision model

(Contributor)

1 edition

North of England and Scotland Study of Tonsillectomy and Adeno-tonsillectomy in Children (NESSTAC) : a pragmatic randomised controlled trial with a parallel non-randomised preference study

(Contributor)

1 edition

A randomised controlled multicentre trial of treatments for adolescent anorexia nervosa including assessment of cost-effectiveness and patient acceptability - the TOuCAN trial

(Contributor)

1 edition

The clinical effectiveness and cost-effectiveness of topotecan for small cell lung cancer: a systematic review and economic evaluation

(Contributor)

1 edition

Antenatal screening for haemoglobinopathies in primary care : a cohort study and cluster randomised trial to inform a simulation model : the Screening for Haemoglobinopathies in First Trimester (SHIFT

(Contributor)

1 edition

Early referral strategies for management of people with markers of renal disease: a systematic review of the evidence of clinical effectiveness, cost-effectiveness and economic analysis

(Contributor)

1 edition

A systematic review and economic evaluation of the clinical effectiveness and cost-effectiveness for aldosterone antagonists for postmyocardial infarction heart failure

(Contributor)

1 edition

Avoiding and identifying errors in health technology assessment models : qualitative study and methodological review

(Contributor)

1 edition

BoTULS : a multicentre randomised controlled trial to evaluate the clinical effectiveness and cost-effectiveness of treating upper limb spasticity due to stroke with botulinum toxin type A

(Contributor)

1 edition

The safety and effectiveness of different methods of earwax removal : a systematic review and economic evaluation

(Contributor)

1 edition

Systematic review of the clinical effectiveness and cost-effectiveness of rapid point-of-care tests for the detection of genital chlamydia infection in women and men

(Contributor)

1 edition

School-linked sexual health services for young people (SSHYP) : a survey and systematic review concerning current models, effectiveness and research opportunities

(Contributor)

1 edition

Systematic review and cost-effectiveness of 'pill-in-the-pocket' strategy for paroxysmal atrial fibrillation compared to episodic in-hospital treatment or continuous antiarrhythmic drug therapy

(Contributor)

1 edition

H1N1 influenza and pandemic flu

(Contributor)

1 edition

Randomised controlled trial and parallel economic evaluation of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR)

(Contributor)

1 edition

Sugammadex for the reversal of muscle relaxation in general anaesthesia : a systematic review and economic assessment

(Contributor)

1 edition

Towards single embryo transfer? : modelling clinical outcomes of potential treatment choices using multiple data sources : predictive models and patient perspectives

(Contributor)

1 edition

Systematic review and economic modelling of the effectiveness and cost-effectiveness of non-surgical treatments for women with stress urinary incontinence

(Contributor)

1 edition

A multicentred randomised controlled trial of a primary care-based cognitive behavioural programme for low back pain. The Back Skills Training (BeST) trial

(Contributor)

1 edition

Recombinant human growth hormone for the treatment of growth disorders in children : a systematic review and economic evaluation

(Contributor)

1 edition

A pragmatic randomised controlled trial to compare antidepressants with a community-based psychosocial intervention for the treatment of women with postnatal depression: the RESPOND trial

(Contributor)

1 edition

Group cognitive behavioural therapy for postnatal depression: a systematic review of clinical effectiveness, cost-effectiveness and value of information analyses

(Contributor)

1 edition

HINI influenza and pandemic flu

(Contributor)

2 editions

A systematic review of positron emission tomography (PET) and positron emission tomography/computed tomography (PET/CT) for the diagnosis of breast cancer recurrence

(Contributor)

1 edition

Systematic review of the links between human resource management practices and performance

(Contributor)

1 edition

Clinical effectiveness and cost-effectiveness of stem cell transplantation in the management of acute leukaemia : a systematic review

(Contributor)

1 edition

An evidence synthesis of qualitative and quantitative research on component intervention techniques, effectiveness, cost-effectiveness, equity and acceptability of different versions of health-related

(Contributor)

1 edition

A multicentre randomised controlled trial and economic evaluation of ion-exchange water softeners for the treatment of eczema in children : the Softened Water Eczema Trial (SWET)

(Contributor)

1 edition

Accuracy of bacterial DNA testing for central venous catheter-associated bloodstream infection in children with cancer

(Contributor)

1 edition

Etanercept, infliximab and adalimumab for the treatment of psoriatic arthritis : a systematic review and economic evaluation

(Contributor)

1 edition

Growth monitoring for short stature : update of a systematic review and economic model

(Contributor)

1 edition

A randomised controlled trial of post-operative radiotherapy following breast-conserving surgery in a minimum-risk population : quality of life at 5 years in the PRIME trial

(Contributor)

1 edition

VenUS III : a randomised controlled trial of therapeutic ultrasound in the management of venous leg ulcers

(Contributor)

1 edition

Adalimumab, etanercept, infliximab, rituximab and abatacept for the treatment of rheumatoid arthritis after the failure of a tumour necrosis factor inhibitor : a systematic review and economic evaluat

(Contributor)

1 edition

Processes in recruitment to randomised controlled trials of medicines for children (RECRUIT) : a qualitative study

(Contributor)

1 edition

The RATPAC (Randomised Assessment of Treatment using Panel Assay of Cardiac markers) trial : a randomised controlled trial of point-of-care cardiac markers in the emergency department

(Contributor)

1 edition

Evidence Review Group approaches to the critical appraisal of manufacturer submissions for the NICE STA process : a mapping study and thematic analysis

(Contributor)

1 edition

A pragmatic single-blind randomised controlled trial and economic evaluation of the use of leukotriene receptor antagonists in primary care at steps 2 and 3 of the national asthma guidelines (ELEVATE

(Contributor)

1 edition

Evaluation of patient reporting of adverse drug reactions to the UK 'Yellow Card Scheme' : literature review, descriptive and qualitative analyses, and questionnaire surveys

(Contributor)

1 edition

Hysterectomy, endometrial ablation and Mirena for heavy menstrual bleeding : a systematic review of clinical effectiveness and cost-effectiveness analysis

(Contributor)

1 edition

An economic evaluation of positron emission tomography (PET) and positron emission tomography/computed tomography (PET/CT) for the diagnosis of breast cancer recurrence

(Contributor)

1 edition

Clinical effectiveness and cost-effectiveness of imatinib dose escalation for the treatment of unresectable and/or metastatic gastrointestinal stromal tumours that have progressed on treatment at a do

(Contributor)

1 edition

Conservative treatment for urinary incontinence in men after prostate surgery (MAPS) : two parallel randomised controlled trials

(Contributor)

1 edition

Bone-anchored hearing aids (BAHAs) for people who are bilaterally deaf : a systematic review and economic evaluation

(Contributor)

1 edition

Diagnostic management strategies for adults and children with minor head injury : a systematic review and an economic evaluation

(Contributor)

1 edition

A study of the safety and harms of antidepressant drugs for older people : a cohort study using a large primary care database

(Contributor)

1 edition

Development and evaluation by a cluster randomised trial of a psychosocial intervention in children and teenagers experiencing diabetes : the DEPICTED study

(Contributor)

1 edition

Identification of risk factors by systematic review and development of risk-adjusted models for surgical site infection

(Contributor)

1 edition

Clopidogrel and modified-release dipyridamole for the prevention of occlusive vascular events (review of Technology Appraisal No. 90) : a systematic review and economic analysis

(Contributor)

1 edition

EVerT: cryotherapy versus salicylic acid for the treatment of verrucae : a randomised controlled trial

(Contributor)

1 edition

The clinical effectiveness and cost-effectiveness of different surveillance mammography regimens after the treatment for primary breast cancer : systematic reviews, registry database analyses and econ

(Contributor)

1 edition

Hemiarthroplasty and total hip arthroplasty for treating primary intracapsular fracture of the hip : a systematic review and cost-effectiveness analysis

(Contributor)

1 edition

Adaptive e-learning to improve dietary behaviour : a systematic review and cost-effectiveness analysis

(Contributor)

1 edition

Insulin sensitisers in the treatment of non-alcoholic fatty liver disease : a systematic review

(Contributor)

1 edition

The clinical effectiveness and cost-effectiveness of management strategies for sciatica : systematic review and economic model

(Contributor)

1 edition

A systematic review and economic evaluation of cilostazol, naftidrofuryl oxalate, pentoxifylline and inositol nicotinate for the treatment of intermittent claudication in people with peripheral arteri

(Contributor)

1 edition

The clinical effectiveness and cost-effectiveness of bortezomib and thalidomide in combination regimens with an alkylating agent and a corticosteroid for the first-line treatment of multiple myeloma :

(Contributor)

1 edition

Lapatinib and trastuzumab in combination with an aromatase inhibitor for the first-line treatment of metastatic hormone receptor-positive breast cancer which over-expresses human epidermal growth fact

(Contributor)

1 edition

Evaluating meta-ethnography : systematic analysis and synthesis of qualitative research

(Contributor)

1 edition

The clinical effectiveness and cost-effectiveness of exercise referral schemes : a systematic review and economic evaluation

(Contributor)

1 edition

A 1-year follow-on study from a randomised, head-to-head, multicentre, open-label study of two pandemic influenza vaccines in children

(Contributor)

1 edition

Development of a social inclusion index to capture subjective and objective life domains (Phase II) : psychometric development study

(Contributor)

1 edition

Pulse oximetry as a screening test for congenital heart defects in newborn infants : a test accuracy study with evaluation of acceptability and cost-effectiveness

(Contributor)

1 edition

Verteporfin photodynamic therapy for neovascular age-related macular degeneration : cohort study for the UK

(Contributor)

1 edition

What is the clinical effectiveness and cost effectiveness of using drugs in treating obese patients in primary care? : a systematic review

(Contributor)

1 edition

Non-invasive diagnostic assessment tools for the detection of liver fibrosis in patients with suspected alcohol-related liver disease : a systematic review and economic evaluation

(Contributor)

1 edition

A systematic review of prevention and intervention strategies for populations at high risk of engaging in violent behaviour : update 2002-8

(Contributor)

1 edition

An evaluation of the feasibility, cost and value of information of a multicentre randomised controlled trial of intravenous immunoglobulin for sepsis (severe sepsis and septic shock) : incorporating a

(Contributor)

1 edition

Group art therapy as an adjunctive treatment for people with schizophrenia : a randomised controlled trial (MATISSE)

(Contributor)

1 edition

The UK EndoVascular Aneurism Repair (EVAR) trials : randomised trials of EVAR versus standard therapy

(Contributor)

1 edition

A pragmatic randomised controlled trial to evaluate the cost-effectiveness of a physical activity intervention as a tratment for depression : the treating depression with physical activity (TREAD) tri

(Contributor)

1 edition

Management of frozen shoulder : a systematic review and cost-effectiveness analysis

(Contributor)

1 edition

A systematic review of the clinical effectiveness and cost-effectiveness of Pharmalgen [superscript circled R] for the treatment of bee and wasp venom allergy

(Contributor)

1 edition

CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study : the effect of tranexamic acid in traumatic brain injury - a nested, randomised, placebo

(Contributor)

1 edition

EOS 2D/3D X-ray imaging system : a systematic review and economic evaluation

(Contributor)

1 edition

Systematic review and validation of prediction rules for identifying children with serious infections in emergency departments and urgent-access primary care

(Contributor)

1 edition

Outcomes of social care for adults : developing a preference-weighted measure

(Contributor)

1 edition

Elucigene FH20 and LIPOchip for the diagnosis of familial hypercholesterolaemia : a systematic review and economic evaluation

(Contributor)

1 edition

Clinical effectiveness and cost-effectiveness of endobronchial and endoscopic ultrasound relative to surgical staging in potentially resectable lung cancer : results from the ASTER randomised controll

(Contributor)

1 edition

The effectiveness of interventions to treat severe acute malnutrition in young children : a systematic review

(Contributor)

1 edition

The clinical effectiveness and cost-effectiveness of home-based, nurse-led health promotion for older people : a systematic review

(Contributor)

1 edition

The effectiveness and cost-effectiveness of donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer's disease (review of Technology appraisal No. 111) : a systematic review a

(Contributor)

1 edition

Dasatinib and nilinib for imatinib-resistant or -intolerant chronic myeloid leukaemia : a systematic review and economic evaluation

(Contributor)

1 edition

Dasatinib, high-dose imatinib and nilotinib for the treatment of imatinib-resistant chronic myeloid leukaemia : a systematic review and economic evaluation

(Contributor)

1 edition

Screening for cystic fibrosis-related diabetes : a systematic review

(Contributor)

1 edition

A methodological study to compare survey-based and observation-based evaluations of organisational and safety cultures and then compare both approaches with markers of the quality of care

(Contributor)

1 edition

Dasatinib and nilotinib for imatinib-resistant or -intolerant chronic myeloid leukaemia : a systematic review and economic evaluation

(Contributor)

1 edition

Clinical effectiveness, cost-effectiveness and service users' perceptions of early, well-resourced communication therapy following a stoke : a randomised controlled trial (the ACT NoW study)

(Contributor)

1 edition

Mode of data elicitation, acquisition and response to surveys : a systematic review

(Contributor)

1 edition

The clinical effectiveness and cost-effectiveness of low-intensity psychological interventions for the secondary prevention of relapse after depression : a systematic review

(Contributor)

1 edition

Surveillance for ocular hypertension : an evidence synthesis and economic evaluation

(Contributor)

1 edition

The measurement of patients' expectations for health care : a review and psychometric testing of a measure of patients' expectations

(Contributor)

1 edition

Interventions to reduce or prevent obesity in pregnant women : a systematic review

(Contributor)

1 edition

Developing and testing methods for deriving preference-based measures of health from condition-specific measures (and other patient-based measures of outcome)

(Contributor)

1 edition

Non-pharmacological interventions to reduce the risk of diabetes in people with impaired glucose regulation : a systematic review and economic evaluation

(Contributor)

1 edition

The clinical effectiveness and cost-effectiveness of technologies used to visualise the seizure focus in people with refractory epilepsy being considered for surgery : a systematic review and decision

(Contributor)

1 edition

The effectiveness and cost-effectiveness of enzyme and substrate replacement therapies : a longitudinal cohort study of people with lysosomal storage disorders

(Contributor)

1 edition

Systematic review and economic modelling of the relative clinical benefit and cost-effectiveness of laparoscopic surgery and robotic surgery for removal of the prostate in men with localised prostate

(Contributor)

1 edition

The use of MElatonin in children with Neurodevelopmental Disorders and impaired Sleep : a randomised, double-blind, placebo-controlled, parallel study (MENDS)

(Contributor)

1 edition

The clinical effectiveness and cost-effectiveness of primary stroke prevention in children with sickle cell disease : a systematic review and economic evaluation

(Contributor)

1 edition

Adapting health promotion interventions to meet the needs of ethnic minority groups : mixed-methods evidence synthesis

(Contributor)

1 edition

Systematic review of head cooling in adults after traumatic brain injury and stroke

(Contributor)

1 edition

Informing a decision framework for when NICE should recommend the use of health technologies only in the context of an appropriately designed programme of evidence development

(Contributor)

1 edition

Types of urethral catheter for reducing symptomatic urinary tract infections in hospitalised adults requiring short-term catheterisation : multicentre randomised controlled trial and economic evaluati

(Contributor)

1 edition

REMCARE : reminiscence groups for people with dementia and their family caregivers - effectiveness and cost-effectiveness pragmatic multicentre randomised trial

(Contributor)

1 edition

Dasatinib, nilotinib and standard-dose imatinib for the first-line treatment of chronic myeloid leukaemia : systematic reviews and economic analyses

(Contributor)

1 edition

Managing Injuries of the Neck Trial (MINT) : a randomised controlled trial of treatments for whiplash injuries

(Contributor)

1 edition